NAFLD és a korai glükagonválasz összefüggése a PNPLA3 RS738409 genotípussal
نویسندگان
چکیده
منابع مشابه
A New PCR-RFLP Method for Diagnosing PNPLA3 rs738409 Polymorphism
Article ID: WMC002401 Article Type: Research Protocol Submitted on:01-Nov-2011, 12:31:07 PM GMT Published on: 02-Nov-2011, 05:42:47 PM GMT Article URL: http://www.webmedcentral.com/article_view/2401 Subject Categories:GENETICS
متن کاملAssociation of rs738409 Polymorphism in the PNPLA3 Gene with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated incidence of 20%–30% in the general population and 67%–75% in the obese population. Genetic predisposition can play an important role in development of this disease. Nonsynonymous coding SNP rs738409 C/G (I148Met) in the PNPLA3 gene has been found to be associated with the presence of...
متن کاملPNPLA3 and TNF-α G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD
Introduction: There is growing evidence that genetic and environmental factors play an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). We investigated the association of single nucleotide polymorphism (SNP) rs738409 in PNPLA3 gene and TNF-α G238A polymorphism with the development and severity of NAFLD in an overweight and obese Egyptian population...
متن کاملPNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C.
BACKGROUND Hepatitis C virus (HCV) is associated with a higher prevalence of steatosis compared to the general population. AIM Our aim was to assess the impact of PNPLA3 rs738409 G-allele on steatosis in HCV patients. MATERIAL AND METHODS We included 474 HCV patients treated with peginterferon plus ribavirin. PNPLA3 rs738409 was genotyped and patients were classified according to alleles an...
متن کاملAdditive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population
Recent genome-wide association studies have identified that variants in or near PNPLA3, NCAN, GCKR, LYPLAL1, and TM6SF2 are significantly associated with non-alcoholic fatty liver disease (NAFLD) in multiple ethnic groups. Studies on their impact on NAFLD in Han Chinese are still limited. In this study, we examined the relevance of these variants to NAFLD in a community-based Han Chinese popula...
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ژورنال
عنوان ژورنال: Diabetologia Hungarica
سال: 2020
ISSN: 1217-372X,2560-0168
DOI: 10.24121/dh.2020.s1.59